ADE: an integrated bioinformatics web server for neurodegenerative disease exploration, omics data

Jiannan Liu (1), Huanmei Wu (2,1), Daniel H. Robertson (3), Kun Huang (4), Jie Zhang (5) 1. Dept of BioHealth Informatics, Indiana University School of Informatics and Computing, Indianapolis, IN, USA. 2. Dept of Health Services Administration & Policy, Temple University College of Public Health, Philadelphia, PA, USA. 3. Indiana Biosciences Research Institute, Indianapolis, IN, USA. 4. Dept of Biostatistics & Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA. 5. Dept of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.

In this study, we developed an AD/ND-oriented web server that provides rich bioinformatics data analysis tools for AD/ND disease exploration. It provides bioinformatic data and analytical tool support for scientists in the ND field but with limited bioinformatics skills, and serves as a one-stop website for AD/ND researchers to find bioinformatics support for hypothesis generation and validation. ADE is designed to have five functional modules: PubAD, GeneAD, ToolboxAD, TargetAD, and DataAD. ADE is structured to address the bioinformatics needs of full AD research life cycle and will accelerate the drug discovery process to finally stop or reverse the AD progression.