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Mingyai Li, PhD


Professor of Biostatistics in Biostatistics and Epidemiology
Senior Scholar, Center for Clinical Epidemiology and Biostatistics

Director of Biostatistics, Gene Therapy Program
Director, Statistical Center for Single-Cell and Spatial Genomics

University of Pennsylvania Perelman School of Medicine


Dr. Mingyao Li joined the Biostatistics faculty in 2006. She is also a faculty member of the Genomics and Computational Biology graduate program. Her main research area is statistical genetics and genomics. The central theme of her current research is to use statistical and machine learning approaches to understand cellular heterogeneity in human disease relevant tissues, to characterize gene expression diversity across cell types, and to study the patterns of cell state transition and crosstalk of various cells using data generated from single-cell transcriptomics studies. In addition to methods development, Dr. Li is also interested in collaborating with researchers seeking to identify complex disease susceptibility genes. Her collaborative research includes cardiometabolic diseases, age-related macular degeneration, Alzheimer's disease, chronic kidney disease, type 1 diabetes, and cancer. Findings from her research will seed cell-specific functional studies, in vivo modeling, and precision therapeutic targeting of human diseases. Dr. Li actively serves in the scientific community. She is an Associate Editor of Statistics in Biosciences, and was a regular member of the Genomics, Computational Biology and Technology study section and a member of the review committee of the Center for Inherited Disease Research of the NIH. (Source; University of Pennsylvania)

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